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Design of Experiments glossary

Short, precise definitions of the terms you will meet when planning and analyzing experiments.

Aliasing
When two or more effects cannot be told apart because the design varies them in the same pattern.
ANOVA
Analysis of variance: splitting the variation in the data into parts explained by the model and by error.
Box-Behnken design
A response-surface design that runs at the midpoints of the edges of the factor cube.
Central composite design
A response-surface design: a factorial plus axial and centre points, able to fit quadratic models.
Centre point
A run with every factor at its midpoint, usually replicated.
Factor
An input you deliberately change in an experiment, such as temperature or pressure.
Fractional factorial design
A design that runs a carefully chosen fraction of a full factorial.
Full factorial design
A design that runs every combination of the factor levels.
Interaction
When the effect of one factor depends on the level of another.
Lack of fit
A test of whether the model's form is too simple, compared with pure replicate error.
Level
A specific setting of a factor. Two-level designs use a low and a high setting.
Predicted R²
How well the model predicts runs it was not fitted to, based on leave-one-out errors.
Pure error
Variation among replicated runs: the noise the model could never explain.
Randomization
Running the experiments in random order to protect against hidden trends.
Residual
The difference between a measured response and the model's fitted value.
Resolution
How seriously a fractional design confounds effects: higher resolution means less severe aliasing.
Response
The measured outcome you want to improve, such as yield, strength or purity.
Response surface methodology
Fitting a quadratic model to find the factor settings that optimize the response.